In the last decade of aging research, AMPK activity has been linked to healthspan and lifespan.
One study showed:
In another study:
“These findings establish an essential requirement for skeletal muscle AMPK-mediated autophagy in preserving blood glucose levels during prolonged fasting as well as maintaining muscle integrity and mitochondrial function during aging.”
"AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging."
Cell Metabolism Volume 21, Issue 6, p883–890, 2 June 2015.
"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network"
Ageing Research Reviews Volume 11, Issue 2, April 2012, Pages 230–241