In the last decade of aging research, AMPK activity has been linked to healthspan and lifespan.

One study showed:

  • AMPK regulates energy metabolic homeostasis and cell survival during stress.
  • AMPK coordinates signaling of many age-related transcription factor pathways.
  • Responsiveness of AMPK activation declines with aging.
  • Increased AMPK activity extends the lifespan of lower organisms. 

​In another study:
“These findings establish an essential requirement for skeletal muscle AMPK-mediated autophagy in preserving blood glucose levels during prolonged fasting as well as maintaining muscle integrity and mitochondrial function during aging.”


"AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging." 
​Cell Metabolism  Volume 21, Issue 6, p883–890, 2 June  2015.​

"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network"
Ageing Research Reviews Volume 11, Issue 2, April 2012, Pages 230–241