Montclair, NJ, June 20, 2016 – Nexus BioPharma, Inc., (OTC-BB NEXS), a company specializing in the development of a weight loss drug therapy, announced today the appointment of Jeffrey Pessin, Ph.D. as Chairman of the Company’s Scientific Advisory Board. Dr. Pessin is the Judy R. & Alfred A. Rosenberg Professorial Chair in Diabetes Research and Director of the Diabetes Research Center, Department of Medicine at the Albert Einstein College of Medicine. He also serves as Professor in the Departments of Medicine (Endocrinology) and Molecular Pharmacology.
“Dr. Pessin is an internationally recognized research scientist, and he brings specific expertise as the discoverer of our weight loss technology”, said Mr. Warren C. Lau, Chief Executive Officer and President of Nexus BioPharma, Inc. Mr. Lau continued “His breakthrough discovery could result in a safe and effective weight loss treatment for overcoming the obesity and type 2 diabetes epidemics.”
About Nexus BioPharma, Inc. www.nexusbiopharma.com
Nexus BioPharma, Inc. is developing a weight loss drug that activates the AMPK metabolic pathway, the same pathway activated by intense physical exercise.
The underlying biochemistry was described in an article in the journal Cell Metabolism by Claire C. Bastie, and Jeffrey E. Pessin, entitled “Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1”. Cell Metab. 2010 Feb 3;11(2):113-24
In completed pre-clinical trials of the pharmaceutical activation of this pathway, test subjects showed reduced fat mass with no loss of lean muscle mass, plus a higher rate of energy expenditure, increased insulin sensitivity, increased fatty acid oxidation, improved plasma and tissue triglyceride levels, with lower cholesterol. Upon translation of this pharmaceutical activation to humans, these effects are expected to have a significant impact on obesity and diabetes.
Using the most advanced high throughput screening technology, Nexus BioPharma has identified small molecule compounds in a number of discrete chemical structure families that can efficiently activate the pathway. The Company has filed for intellectual property protection on a selection of compounds in a number of discrete chemical backbones. The Company’s goal is to advance to pre-IND trials in preparation for FDA human trials of a drug that will safely mimic this effect in humans.
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